March 6th, 2024

Herewith RMR update #12! Nothing dramatic to report this time; we are at that tantalising phase where lots of mice are dying but not quite enough has happened to allow any firm conclusions. I've bitten the bullet and extended the plot area down to 0% survival - it seems like the right time to do that.

At this stage, around the peak in terms of absolute numbers of deaths per month, one thing to bear in mind is that we expect to see a lot of noise, with curves changing places in terms of ranking - and so we are. But I'm delighted to note that the all-treatments group is still taking roughly twice as long as the all-controls group (starting from 19 months old, when the experiment began) to get down to a given survival percentage in males, albeit only about 50% longer than controls in females.

It'll still be a few months before we can start to discern whether this persists well enough to constitute the Holy Grail of a true lengthening of mortality rate doubling time. Fingers crossed!